abstract：:Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...

journal_title：BioMed research international

authors： Matsubara E,Takamura A,Okamoto Y,Oono H,Nakata T,Wakasaya Y,Kawarabayashi T,Shoji M

更新日期：2013-01-01 00:00:00

abstract：AIM:Cardiac rehabilitation (CR) is an important part of heart failure (HF) treatment. The aim of this paper was to evaluate if thoracic fluid content (TFC) measured by impedance cardiography (ICG) is a useful parameter for predicting the outcome of CR. METHODS:Fifty HF patients underwent clinical and noninvasive haemo...

journal_title：BioMed research international

authors： Gielerak G,Krzesiński P,Piotrowicz E,Piotrowicz R

更新日期：2013-01-01 00:00:00

abstract：:The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...

journal_title：BioMed research international

authors： Kumar S,Chashoo G,Saxena AK,Pandey AK

更新日期：2013-01-01 00:00:00

abstract：:Subtle perturbations in intraglomerular VEGF/VEGFR-2 signaling or in the influencing microenvironment can profoundly affect renal function, resulting in the apparently paradoxical observation that VEGF blockade attenuates proteinuria development in experimental diabetes despite exerting the opposite effect under other...

journal_title：BioMed research international

authors： Advani A,Connelly KA,Advani SL,Thai K,Zhang Y,Kelly DJ,Gilbert RE

更新日期：2013-01-01 00:00:00

abstract：:Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...

journal_title：BioMed research international

authors： Chen S,Meng XF,Zhang C

更新日期：2013-01-01 00:00:00

abstract：:Background. Genome-wide association studies (GWAS) have shown its revolutionary power in seeking the influenced loci on complex diseases genetically. Thousands of replicated loci for common traits are helpful in diseases risk assessment. However it is still difficult to elucidate the variations in these loci that dire...

journal_title：BioMed research international

authors： Ma LX,Wang YJ,Wang JF,Li X,Hao P

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...

journal_title：BioMed research international

authors： Bilge U,Unluoglu I,Son N,Keskin A,Korkut Y,Unalacak M

更新日期：2013-01-01 00:00:00

abstract：:Influences of environmental variables and emulsifiers on lipase production of a Candida viswanathii strain were investigated. The highest lipase activity (101.1 U) was observed at 210 rpm, pH 6.0, and 27.5°C. Other fermentation parameters analyzed showed considerable rates of biomass yield (Y L/S = 1.381 g/g), lipase ...

journal_title：BioMed research international

authors： de Almeida AF,Tauk-Tornisielo SM,Carmona EC

更新日期：2013-01-01 00:00:00

abstract：:A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solv...

journal_title：BioMed research international

authors： Tan L,Xu X,Song J,Luo F,Qian Z

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...

journal_title：BioMed research international

authors： Goldman SM,Nunes TF,Melo HJ,Dalavia C,Szejnfeld D,Kater C,Andreoni C,Szejnfeld J,Ajzen SA

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:Isoniazid (INH), a key agent in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic N-acetyltransferase 2 (NAT2) enzyme. Patients treated with INH can be classified as fast, intermediate, and slow acetylators. The objective of this study was to explore the relationship...

journal_title：BioMed research international

authors： Zabost A,Brzezińska S,Kozińska M,Błachnio M,Jagodziński J,Zwolska Z,Augustynowicz-Kopeć E

更新日期：2013-01-01 00:00:00

abstract：:Studies on the occurrence of pharmaceuticals show that the widely used pharmaceuticals ibuprofen and diclofenac are present in relevant concentrations in the environment. A pilot plant treating hospital wastewater with relevant concentrations of these pharmaceuticals was evaluated for its performance to reduce the con...

journal_title：BioMed research international

authors： Langenhoff A,Inderfurth N,Veuskens T,Schraa G,Blokland M,Kujawa-Roeleveld K,Rijnaarts H

更新日期：2013-01-01 00:00:00

abstract：OBJECT:Video-assisted thoracoscopic sympathectomy is a safe, effective, and minimally invasive procedure for primary hyperhidrosis. This study aims to evaluate long-term results and patients' quality of life and investigate potential variables responsible for compensatory sweating after one-stage bilateral single-port ...

journal_title：BioMed research international

authors： Ibrahim M,Menna C,Andreetti C,Ciccone AM,D'Andrilli A,Maurizi G,Pomes LM,Cassiano F,Venuta F,Rendina EA

更新日期：2013-01-01 00:00:00

abstract：:It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...

journal_title：BioMed research international

authors： Hazelhoff MH,Bulacio RP,Torres AM

更新日期：2013-01-01 00:00:00

abstract：:Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...

journal_title：BioMed research international

authors： Xing R,Liu S,Yu H,Chen X,Qin Y,Li K,Li P

更新日期：2013-01-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) remains a leading cause of iatrogenic acute kidney injury, as the usage of contrast media for imaging and intravascular intervention keeps expanding. Diabetes is an important predisposing factor for CIN, particularly in patients with renal functional impairment. Renal hypoxia, combin...

journal_title：BioMed research international

authors： Heyman SN,Rosenberger C,Rosen S,Khamaisi M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The genome-wide association studies (GWAS) have been successful during the last few years. A key challenge is that the interpretation of the results is not straightforward, especially for transacting SNPs. Integration of transcriptome data into GWAS may provide clues elucidating the mechanisms by which a gen...

journal_title：BioMed research international

authors： Jiang G,Chakraborty A,Wang Z,Boustani M,Liu Y,Skaar T,Li L

更新日期：2013-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

journal_title：BioMed research international

authors： Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

更新日期：2013-01-01 00:00:00

abstract：:Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...

journal_title：BioMed research international

authors： Mennan C,Wright K,Bhattacharjee A,Balain B,Richardson J,Roberts S

更新日期：2013-01-01 00:00:00

abstract：:We study the interaction of 3T3 Swiss albino mouse fibroblasts with polymeric nanoparticles (NPs) and investigate cellular behaviour in terms of viability/cytotoxicity, cell cycle, NPs uptake, MAP kinase (ERK1/2), and focal adhesion kinase (FAK) activation. After incubation of NPs with cell culture media, western blot...

journal_title：BioMed research international

authors： Rosso F,Marino G,Grimaldi A,Cafiero G,Chiellini E,Chiellini F,Barbarisi M,Barbarisi A

更新日期：2013-01-01 00:00:00

abstract：:Dysfunctions of chaperone-mediated autophagy (CMA), the main catabolic pathway for alpha-synuclein, have been linked to the pathogenesis of Parkinson's disease (PD). Since till now there is limited information on how PD-related toxins may affect CMA, in this study we explored the effect of mitochondrial complex I inhi...

journal_title：BioMed research international

authors： Sala G,Arosio A,Stefanoni G,Melchionda L,Riva C,Marinig D,Brighina L,Ferrarese C

更新日期：2013-01-01 00:00:00

abstract：:The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structu...

journal_title：BioMed research international

authors： Sales-Campos H,Tonani L,Cardoso CR,Kress MR

更新日期：2013-01-01 00:00:00

abstract：:Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...

journal_title：BioMed research international

authors： Kim JL,Kim YH,Kang MK,Gong JH,Han SJ,Kang YH

更新日期：2013-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues. Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL). Such complex...

journal_title：BioMed research international

authors： Kiczak L,Tomaszek A,Bania J,Paslawska U,Zacharski M,Noszczyk-Nowak A,Janiszewski A,Skrzypczak P,Ardehali H,Jankowska EA,Ponikowski P

更新日期：2013-01-01 00:00:00

abstract：:Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...

journal_title：BioMed research international

authors： Ronquillo-Sánchez MD,Camacho-Carranza R,Fernandez-Mejia C,Hernández-Ojeda S,Elinos-Baez M,Espinosa-Aguirre JJ

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:In order to establish inspection routines for individual intraocular lenses (IOLs), their surfaces have to be measured separately. Currently available measurement devices lack this functionality. The purpose of this study is to evaluate a new topography measurement device based on wavefront analysis for measuri...

journal_title：BioMed research international

authors： Kannengießer M,Langenbucher A,Janunts E

更新日期：2013-01-01 00:00:00

abstract：:The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administere...

journal_title：BioMed research international

authors： Patel BM,Damle D

更新日期：2013-01-01 00:00:00

abstract：:Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full fact...

journal_title：BioMed research international

authors： Chavda H,Modhia I,Mehta A,Patel R,Patel C

更新日期：2013-01-01 00:00:00

abstract：:A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...

journal_title：BioMed research international

authors： Bakshi S,Sa PK,Majhi B

更新日期：2013-01-01 00:00:00

abstract：:This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms. Data on cumul...

journal_title：BioMed research international

authors： Franko A,Dolžan V,Arnerić N,Dodič-Fikfak M

更新日期：2013-01-01 00:00:00

abstract：:Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usefulness because they...

journal_title：BioMed research international

authors： Iida A,Takino N,Miyauchi H,Shimazaki K,Muramatsu S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache...

journal_title：BioMed research international

authors： Motaghi M,Haghjooy Javanmard S,Haghdoost F,Tajadini M,Saadatnia M,Rafiee L,Zandifar A

更新日期：2013-01-01 00:00:00

abstract：:In vitro research performed on eukaryotic or prokaryotic cell cultures usually represents the initial step for characterization of a novel photosensitizer (PS) intended for application in photodynamic therapy (PDT) of cancer or photodynamic inactivation (PDI) of microorganisms. Although many experimental steps of PS t...

journal_title：BioMed research international

authors： Kiesslich T,Gollmer A,Maisch T,Berneburg M,Plaetzer K

更新日期：2013-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is glucose-dependent insulinotropic hormone secreted from enteroendocrine L cells. Its long-acting analogue, exendin-4, is equipotent to GLP-1 and is used to treat type 2 diabetes mellitus. In addition, exendin-4 has effects on the central and peripheral nervous system. In this study, w...

journal_title：BioMed research international

authors： Yamamoto K,Amako M,Yamamoto Y,Tsuchihara T,Nukada H,Yoshihara Y,Arino H,Fujita M,Uenoyama M,Tachibana S,Nemoto K

更新日期：2013-01-01 00:00:00

abstract：:We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...

journal_title：BioMed research international

authors： Zhang Y,Ye C,Wang G,Gao Y,Tan K,Zhuo Z,Liu Z,Xia H,Yang D,Li P

更新日期：2013-01-01 00:00:00

abstract：:The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male Albino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified test diets for eight weeks. The first group (G1) is the negati...

journal_title：BioMed research international

authors： El Rabey HA,Al-Seeni MN,Amer HM

更新日期：2013-01-01 00:00:00

abstract：:This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be de...

journal_title：BioMed research international

authors： Chen M,Bao Y,Ma HL,Hu X,Wang J,Wang Y,Peng F,Zhou QC,Xie CH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Chemokine/receptor axis is a predominant actor of clinical disorders. They are key factors of pathogenesis of almost all clinical situations including asthma. Correspondingly, CXCL12 is involved in the immune responses. Therefore, this study was designed to explore the association between gene polymo...

journal_title：BioMed research international

authors： Rafatpanah H,Amin M,Ghasemshirazi M,Kazemiarababadi M,Khorramdelazad H,Abousaidi H,Shabani Z,Sayadi A,Hassanshahi G,Samadi J

更新日期：2013-01-01 00:00:00

abstract：:Aspergillus species originating from Greece were examined by morphological and molecular criteria to explore the diversity of this genus. The phylogenetic relationships of these species were determined using sequences from the ITS and IGS region of the nuclear rRNA gene complex, two nuclear genes ( β -tubulin (benA) a...

journal_title：BioMed research international

authors： Krimitzas A,Pyrri I,Kouvelis VN,Kapsanaki-Gotsi E,Typas MA

更新日期：2013-01-01 00:00:00

abstract：:A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated by a lag phase. Th...

journal_title：BioMed research international

authors： Khan Z,Choonara YE,Kumar P,du Toit LC,Ndesendo VM,Pillay V

更新日期：2013-01-01 00:00:00